Fluconazole therapy has been associated with QT interval prolongation, which may lead to serious cardiac arrhythmias. Mayo Clinic Marketplace Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. If taken at these doses, the pregnancy category side effects of diflucan changed from category C to category D. To our knowledge, our study is the second documented case of successful patch testing for fluconazole [ 6 ].
We discuss a rare case of fixed drug eruption due to fluconazole. In general, the body tolerates fluconazole quite well. Fluconazole has also rarely been associated with severe or lethal hepatotoxicity , so liver function tests are usually performed regularly during prolonged fluconazole therapy. However, high doses have been associated with a rare and distinct set of birth defects in infants. Written informed consent was obtained from the patient for publication of this case report and any accompanying images. However, we did an oral test as well that was also positive.
Find a comprehensive guide to possible side effects including common and rare side effects when taking Diflucan (Fluconazole) for healthcare professionals.
Diflucan Australian Approved Product Information. Thus, it is used with caution in patients with risk factors for prolonged QT interval, such as electrolyte imbalance or use of other drugs that may prolong the QT interval particularly cisapride and pimozide. Alanko conducted a topical provocation test on 30 patients with FDE and concluded that the test is a useful and safe method. Fixed drug eruption FDE is characterized by single or multiple skin lesions that occur at the same site each time a drug is administered. Conclusion Fluconazole is a widely prescribed drug, used mainly to treat candidiasis. Fixed drug eruption induced by fluconazole, upper lip area. Drugs causing fixed eruptions:
Based on our findings, which are consistent with a number of other practitioners, we recommend adding fixed drug eruption to the list of possible side effects of fluconazole. Although not all of these side effects may occur, if they do occur they may need medical attention. Fluconazole is an inhibitor of the human cytochrome P system, particularly the isozyme CYP2C19 CYP3A4 and CYP2C9 to lesser extent  In theory, therefore, fluconazole decreases the metabolism and increases the concentration of any drug metabolised by these enzymes.
Fixed drug eruption due to fluconazole. However, the higher ratio of women could be due to the higher prescription of fluconazole to women due to vaginal candidiasis. A year-old woman received five doses of fluconazole mg once a month for recurrent vaginal candidiasis. Common side effects include vomiting, diarrhea, rash, and increased liver enzymes. A young woman with recurrent vesicles on the lower lip: Swelling and redness of skin are typically seen within 30 minutes to eight hours after exposure.
However, high doses have been associated with a rare and distinct set of birth defects in infants. Pregnancy category D means there is positive evidence of human fetal risk based on human data.
Fixed drug eruption due to fluconazole right popliteal area. A report of vulvar FDE due to fluconazole has also been published recently [ 15 ]. However, FDE may be misdiagnosed and mistreated since many medical practitioners are unaware of this uncommon side effect. Conclusion Fluconazole is a widely prescribed drug, used mainly to treat candidiasis.
Fluconazole is a first-generation triazole antifungal medication. Some side effects may occur that usually do not need medical attention. This content does not have an English version.
Fluconazole is a widely used antifungal agent with a possible side effect of fixed drug eruption. Again, the patches faded and hyperpigmented areas developed.
The more common side effects of fluconazole oral tablet depend on how much of the drug you need to take. These side effects can include.
Centers for Medicare and Medicaid Services. Side effects of diflucan this time, we recommended that she use other contraceptive methods for example, condoms. A young woman with recurrent vesicles on the lower lip: Fluconazole was patented in and came into commercial use in In a bulk powder form, it appears as a white crystalline powder, and it is very slightly soluble in water and soluble in alcohol.
Case presentation A year-old woman received five doses of fluconazole mg once a month for recurrent vaginal candidiasis. They also reported that
Find patient medical information for Fluconazole Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
Fluconazole or Diflucan Medication Information (dosing, side effects, patient counseling)
One study demonstrated that an oral challenge test is a useful method as a tolerance test or to exclude drug hypersensitivity in cases of suspected drug reactions with negative skin tests [ 19 ]. These side effects may go away during treatment as your body adjusts to the medicine. Advertising revenue supports our not-for-profit mission. Observed hypersensitivity reactions are anaphylactic reactions, angioedema and facial edema, pruritus, urticaria, erythematous or maculopapular rash and exfoliative skin reactions, including Stevens Johnson Syndrome SJS and toxic epidermal necrolysis [ 3 ].